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Description
human bcrp vesicle kit hek293Das Human BCRP Vesicle Kit enthlt Inside out Membranvesikel aus HEK293 Zellen, die transient das Breast Cancer Resistance Protein (BCRP ABCG2) berexprimieren. Das Kit ermglicht ATP abhngige Substrattransportstudien im High Throughput Format und ist konform mit den FDA (2017) und EMA (2013) Leitlinien zur Charakterisierung von Arzneimittelwechselwirkungen (DDI). Hergestellt von Cell4Pharma. Exklusiv im DACH Raum erhltlich ber SeamlessBio. Transporter
Das Human BCRP Vesicle Kit enthält Inside-out-Membranvesikel aus HEK293-Zellen, die transient das Breast Cancer Resistance Protein (BCRP / ABCG2) überexprimieren. Das Kit ermöglicht ATP abhängige Substrattransportstudien im High-Throughput-Format und ist konform mit den FDA (2017)- und EMA (2013)-Leitlinien zur Charakterisierung von Arzneimittelwechselwirkungen (DDI).
Hergestellt von Cell4Pharma. Exklusiv im DACH-Raum erhältlich über SeamlessBio.
Transporter-Profil
Name: BCRP, Breast Cancer Resistance Protein, ABCG2, ATP-bindende Kassette Unterfamilie G Mitglied 2
Gen: ABCG2
ATP/AMP-Ratio: >10 (garantiert)
Gewebsexpression: Plazenta, Stammzellen, Prostata, Dünndarm, Gehirn, Dickdarm, Leber, Brustdrüse, Niere
Bekannte Substrate: Estron-3-Sulfat (E1S), Methotrexat, Irinotecan, Pantoprazol, Rosuvastatin, Topotecan, Chlorothiazid, Mitoxantron, SN-38, Glibenclamid
Kit-Inhalt (100 Reaktionen)
- Vesikel-Vial (100 Reaktionen), BCRP-überexprimierende
- HEK293-abgeleitete Vesikel
- AMP-ATP-Lösung (100 mM), Cell4Pharma
- Assay-Puffer, Cell4Pharma
Anwendungen
- Identifikation von Efflux-Transporter-Substraten
- Drug-Drug-Interaction-(DDI)-Studien gemäß FDA/EMA-Leitlinien
- Inhibitionsstudien (IC50-Bestimmung)
- High-Throughput-Screening (Radiolabel-, Fluoreszenz-, LC-MS-Detektion)
Regulatorische Konformität
Der vesikuläre Transportassay mit BCRP-Vesikeln wird im FDA Drug
Interaction Guidance (2017) und in der EMA-Leitlinie zur Untersuchung von
Arzneimittelinteraktionen (2013) für die Charakterisierung
transporter-vermittelter DDI in der Arzneimittelentwicklung empfohlen.
Technische Spezifikationen
Wirtszelle: HEK293 (humane embryonale Nierenzelle)
Vesikeltyp: Inside-out-Membranvesikel
Format: 100 Reaktionen pro Kit
Detektion: Radiolabel / Fluoreszenz / LC-MS kompatibel
Lagerung: –80 °C
Verwandte Produkte
- Human Control Vesicle Kit (C4PVK009) – empfohlen als Negativkontrolle in BCRP-Transportassays
- Human Pgp Vesicle Kit (C4PVK010) – für parallele P-gp-Efflux-Messung
- ciPTEC-OAT1 Assay-Ready Cells – für zellbasierte Nephrotoxizitäts- und Transporterstudien
- Human Serum AB Male OTC (SeamlessBio) – zur Supplementierung von ciPTEC-Kulturmedien
Alle Produkte auf Anfrage.
Kontakt: [email protected] | Telefon: +49 851 37932226
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4.7 ★★★★★
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Product Reviews
★★★★★ 5
Really loving this!
This gives such a pretty sun-kissed glow without looking orange or over-the-top glittery. I’ve been using it on my arms and legs and it makes my skin look healthy, hydrated, and glowy without feeling greasy. It’s lightweight, easy to apply, and lasts longer than I expected. Smells good too. Definitely feels like a great value for the money. Perfect for summer, vacations, or when you just want a little extra glow without self tanner.
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Reviewed in the United States on May 17, 2026
★★★★★ 5
Beautiful glow
The way this makes my skin looks is heavenly. I’ve been using it on vacation and it makes my skin feel so smooth. The product is lightweight and doesn’t feel sticky on skin and the shimmer lasts all day. There’s no strong smell which I’m super happy about. Would definitely recommend this.
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Reviewed in the United States on May 27, 2026
★★★★★ 4
Does not stain! Great body oil
It’s soooo light weight and easy to apply, you don’t need tons of it to get a nice result. It’s not very oily nor greasy at all. It DOES NOT STAIN!!!! I love that, it moisturized my skin so well, it looks so pretty and natural but I’m going to mention that the scent is a little weird, not bad but like I was expecting to smell like vanilla but it’s not vanilla… it’s something else but is ok because it’s not strong or unpleasant.
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Reviewed in the United States on May 27, 2026
★★★★★ 5
Smells so good and very moisturizing and not sticky
It smells so good! It’s also pretty glittery and sparkly. I’m usually not a fan of using body oil because I don’t like the stickiness of it on my body, but this body oil is very good! I’ve been mixing this body oil with my regular non-scented lotion(cerave moisturizing cream) after I shower before bed. Though by the time I wake up the next morning, the scent is gone. It’s not necessarily a bad thing since the scent can be a little bit strong when first applied, but overall it’s not too overwhelming and it’s perfect! I really enjoy using this body oil gel!
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Reviewed in the United States on May 29, 2026
★★★★★ 5
Teaaa Baby
This shimmer gel oil is teaaaa on your body. It smells good when combined with a cologne of your choice. It’s non-greasy, moisturizes the skin good and of course gives you that glow on your body needs. You must buy this.
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Reviewed in the United States on May 30, 2026
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