SKU: 81744815182

human bsep vesicle kit hek293

$652.50 $725.00
Save 10%
No.2 Bestseller on martinetexier.com >

Pay in installments of $181.25 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Aug 1 - Aug 6

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

human bsep vesicle kit hek293Das Human BSEP Vesicle Kit enthlt Inside out Membranvesikel aus HEK293 Zellen, die transient die Bile Salt Export Pump (BSEP ABCB11) berexprimieren. BSEP ist der primre hepatische Efflux Transporter fr Gallensalze und ein zentrales Zielprotein in der Risikoabschtzung fr medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017) und EMA (2013) Leitlinien fr DDI Studien. Hergestellt von Cell4Pharma. Exklusiv im DACH Raum erhltlich

Das Human BSEP Vesicle Kit enthält Inside-out Membranvesikel aus HEK293-Zellen, die transient die Bile Salt Export Pump (BSEP / ABCB11) überexprimieren. BSEP ist der primäre hepatische Efflux-Transporter für Gallensalze und ein zentrales Zielprotein in der Risikoabschätzung für medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017)- und EMA (2013) Leitlinien für DDI Studien.
 
Hergestellt von Cell4Pharma. Exklusiv im DACH-Raum erhältlich über SeamlessBio.
 

Transporter-Profil

Name: BSEP, Bile Salt Export Pump, ABCB11, ATP-bindende Kassette Unterfamilie B Mitglied 11
Gen: ABCB11
ATP/AMP-Ratio: >10 (garantiert)

Gewebsexpression: Kanalikuläre Plasmamembran der Hepatozyten

Erkrankungen: Erbliche und medikamenteninduzierte Cholestase (DILI)

Bekannte Substrate:  Taurocholat, Pravastatin, Taurolithocholyl-3-Sulfat, konjugierte monovalente Gallensalze

In stock: Human, Katze, Hund
 

Kit-Inhalt (100 Reaktionen)

  • Vesikel-Vial (100 Reaktionen), BSEP überexprimierende HEK293-abgeleitete Vesikel
  • AMP-ATP-Lösung (100 mM), Cell4Pharma
  • Assay-Puffer, Cell4Pharma

Anwendungen

  • allensalztransport-Inhibitionsstudien (Cholestase-Risikoabschätzung)
  • Drug-Induced Liver Injury (DILI) Screening 
  • Drug-Drug-Interaction-(DDI)-Studien gemäß FDA/EMA-Leitlinien 
  • Substratidentifikation für hepatische Efflux-Transporter
  • High-Throughput-Screening (Radiolabel-, Fluoreszenz-, LC-MS-Detektion)

Regulatorische Konformität

Die Hemmung von BSEP ist ein etablierter Mechanismus der medikamenteninduzierten cholestatischen Leberschädigung. Die Bewertung der BSEP-Hemmung wird in den FDA (2017)- und EMA (2013)-DDI-Leitlinien als Teil des Transporter-Charakterisierungspakets für neue Molekülentitäten (NMEs) in der klinischen Entwicklung empfohlen.
 

Technische Spezifikationen 

Wirtszelle: HEK293 (humane embryonale Nierenzelle)
Vesikeltyp: Inside-out-Membranvesikel
Format: 100 Reaktionen pro Kit
Detektion: Radiolabel / Fluoreszenz / LC-MS kompatibel
Lagerung: –80 °C
 

Verwandte Produkte

  • Human Control Vesicle Kit (C4PVK009) – empfohlen als Negativkontrolle in BCRP-Transportassays
  • Human MRP2 Vesicle Kit (C4PVK002) – for parallel hepatic efflux assessment
  • Human BCRP Vesicle Kit (C4PVK006) – for complete efflux transporter panel
  • ciPTEC-OAT1 Assay-Ready Cells – für zellbasierte Nephrotoxizitäts- und Transporterstudien
  • Human Serum AB Male OTC (SeamlessBio) – zur Supplementierung von ciPTEC-Kulturmedien
Alle Produkte auf Anfrage.
Kontakt: [email protected] | Telefon: +49 851 37932226
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 81744815182

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.2 ★★★★★
Based on 23 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
V
Verified Purchase
Vincent Smith
Whiting, US
★★★★★ 5
Perfect Shoes Work & Happy Hour!
Size: 13 Wide, Color: Blue, Size: 13 Wide, Color: Blue
Working downtown again and occasionally someone will invite me out for Happy Hour after work. So I needed nice shoes for Summer that could take me from my law office to the speakeasy. These are comfy. The little air holes are great for letting out the heat of everyday walking to and from work without being noticeable. My feet can breathe! I'm a size 13 wide and they feel nice, light, with room to spare if I wanted to wear little thicker dress socks or some crew type socks w them. They tie up easy, wipe off fine if I get them a bit muddy in the backyard before work taking out the garbage and they look darn good w out breaking the bank!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 21, 2026
C
Verified Purchase
Chris
Boise, US
★★★★★ 4
9-5 go to Shoe
Size: 9, Color: Black
Shoes arrived today. My knocks on them are the laces and the warmth (my feet soaked only after 4 hours of wear.) but for the price and discount that's currently being offered, no one can beat it. I was in desperate need of new shoes for my office job because my current ones were torn and color faded due to wear and tear, the two pairs that I bought are very stylish, comfortable, and the bottoms are durable and slip resistant. I was also surprised that they're true to size. I wear sneakers and these in size nine.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 15, 2026
M
Verified Purchase
Michael Bruns
Waukegan, US
★★★★★ 5
Comfort and excellent bang for your buck
Size: 10 Wide, Color: Brown
These are incredibly comfortable. I bought them for work, and as someone who works in IT, I'm on my feet a lot, and often crouching down or leaning in awkward positions, and these have been awesome for me. I've never felt they were uncomfortable. They seem to be pretty good quality too, though I am seeing slight creases where I do end up bending my feet while doing my job, but I have already considered buying another pair (and not because of that, just to have another color). I even had a teenage kid say 'nice shoes' to me the other day, and I've had other positive comments from coworkers as well.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 7, 2026
P
Verified Purchase
Paulie G
Draper, US
★★★★★ 5
Nice looking Shoes
Size: 9, Color: Brown
These shoes are very nice. I never heard of the name Bruno Marc before, but I will say the shoes are extremely comfortable, and they look like similar high end shoes at the fraction off the cost. Very light and durable.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 10, 2026
W
Verified Purchase
Wallace Jurkiewicz
Phoenix, US
★★★★★ 5
Comfortable casual dress shoes that look good too
Size: 13, Color: Black
Needed a nice pair of casual dress shoes. These turned out perfect for me. Comfortable and looks good.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 31, 2026

recommand products

peugeot boxer signal mark guard textured
40.00
man tge badgeless grille blanking plate gloss black
31.00
Festool S 75/4/100 Stichsägeblatt WOOD BASIC ( 204346 ) für PS 300, PSB 300, PS 400, PSC 400, PSBC 400, PSB 400, PS 420, PSB 420, PSC 420, PSBC 420
111.87
vw t5 cab divider curtain kit
80.99
Festool STF DELTA 100x150 P80 GR NET/50 Netzschleifmittel Granat Net ( 203320 ) für DTS 400, DTSC 400, DS 400
55.27