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Description
Human TrkB , His tagProduct Specification Species Human Synonyms GP145 TrkB (Trk B), Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin related kinase B, NTRK2 Accession Q16620 Amino Acid Sequence Protein sequence(Q16620, Trp230 His430, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | GP145-TrkB (Trk-B), Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B, NTRK2 |
| Accession | Q16620 |
| Amino Acid Sequence | Protein sequence(Q16620, Trp230-His430, with C-10*His) WDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHGGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:24kDa Actual: 35-45kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
Tropomyosin receptor kinase B is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB are: BDNF (Brain Derived Neurotrophic Factor), neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3). Although originally identified as an oncogenic fusion in 1982, only recently has there been a renewed interest in the Trk family as it relates to its role in human cancers because of the identification of NTRK1 (TrkA), NTRK2 (TrkB) and NTRK3 (TrkC) gene fusions and other oncogenic alterations in a number of tumor types. A number of Trk inhibitors are in clinical trials and have shown early promise in shrinking human tumors. TrkB and its ligand BDNF have been associated to both normal brain function and in the pathology and progression of Alzheimer’s disease (AD) and other neurodegenerative disorders.
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4.6 ★★★★★
Based on 13 reviews
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Product Reviews
★★★★★ 5
LOVE THESE
Size: 3 Little Kid, Color: Hot Pink/Multi
Really nice. Pix don’t do them justice.
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Reviewed in the United States on May 27, 2026
★★★★★ 5
Great for busy feet
Size: 13 Little Kid, Color: Hot Pink/Multi, Size: 13 Little Kid, Color: Hot Pink/Multi
My five-year-old daughter loves these Skechers slip-ins—and she is not easy on her shoes! You can see in the photo, she’s already put plenty of miles on them. They’ve been through the washing machine at least twice and still look great—the bright colors are a big hit with her and they hold up well in the wash.
One of the elastic bands on top did come loose, but I was able to fix it quickly with a dab of superglue. She slips them on and off all by herself, which is perfect as we’re still learning to tie laces. All in all, a great purchase for the price—especially since kids grow so fast and put their shoes through a lot!
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Reviewed in the United States on May 24, 2025
★★★★★ 5
Cute slip-ons - so easy and quick!
Size: 13 Little Kid, Color: Hot Pink/Multi
These shoes are adorable, comfortable according to my kid, and super easy to pull on!
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Reviewed in the United States on January 17, 2026
★★★★★ 5
Durable
Size: 6 Big Kid, Color: Aqua/Multi
Good shoes. True to size
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Reviewed in the United States on February 18, 2026
★★★★★ 5
So good!
Size: 4 Big Kid, Color: Aqua/Multi
As always sketchers give her great support nd comfort while being cute and easy on off! Slip resistant, breathable and size is spot on and super durable wash great and dry quick
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Reviewed in the United States on October 28, 2025