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Description
VGlut1 Recombinant Rabbit mAb (S-1587-19)Product Specification Host Rabbit Antigen VGlut1 Synonyms Vesicular glutamate transporter 1; VGluT1; Brain specific Na(+) dependent inorganic phosphate cotransporter; Solute carrier family 17 member 7; Bnpi; Slc17a7 Immunogen Synthetic Peptide Location Cell membrane, Synapse Accession Q3TXX4 Clone Number S 1587 19 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Hu, Ms, Rt Positive Sample human brain, mouse brain, rat
Product Specification
| Host | Rabbit |
| Antigen | VGlut1 |
| Synonyms | Vesicular glutamate transporter 1; VGluT1; Brain-specific Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 7; Bnpi; Slc17a7 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Synapse |
| Accession | Q3TXX4 |
| Clone Number | S-1587-19 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | human brain, mouse brain, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:2000 | Hu, Ms, Rt |
| IF | 1:500 | Hu, Ms, Rt |
Background
Vesicular glutamate transporter 1 (VGLUT1) is a crucial protein encoded by the SLC17A7 gene, predominantly found in neuron-rich regions of the brain. It is a vesicle-bound, sodium-dependent phosphate transporter that plays a vital role in packaging glutamate into synaptic vesicles, which is essential for excitatory neurotransmission. VGLUT1 is primarily expressed in the neocortex, cerebellum, and hippocampus, and is involved in intercortical and corticothalamic projections. Its function relies on a proton gradient across the vesicular membrane, established by a V-type ATPase, allowing it to couple proton movement out of the vesicle with glutamate transport into it. This protein is also implicated in various neurological disorders, including learning and memory disorders, Alzheimer's disease, and pain pathology.
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