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Description
Fc γ RIIIb/CD16b(NA1) His Tag Protein, HumanProduct Specification Species Human Synonyms Fc RIIIb, CD16b(NA1); Low affinity immunoglobulin gamma Fc region receptor III B, Fc gamma RIII beta, FcR 10, IgG Fc receptor III 1, FCG3, FCGR3, CD16b and FCGR3B. Accession O75015 Amino Acid Sequence Gly17 Ser200(NA1), with C terminal His Expression System HEK293 Molecular Weight 33 40 kDa(Reducing) Purity 95%, by SDS PAGE under reducing conditions Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag
Product Specification
| Species | Human |
| Synonyms | Fc γ RIIIb, CD16b(NA1);Low affinity immunoglobulin gamma Fc region receptor III-B, Fc-gamma RIII-beta, FcR-10, IgG Fc receptor III-1, FCG3, FCGR3, CD16b and FCGR3B. |
| Accession | O75015 |
| Amino Acid Sequence | Gly17-Ser200(NA1), with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 33-40 kDa(Reducing) |
| Purity | ＞95%, by SDS-PAGE under reducing conditions |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation . |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
IgG Fc receptor (Fc γ R) is a member of the Ig superfamily, which plays a role in activating or inhibiting immune response. Human Fc γ Rs is identified as three types: RI (CD64), RII (CD32) and RIII (CD16). CD16 is a low-affinity Fc receptor, which has been identified as Fc receptor Fc γ RIII (a (CD16a) and Fc γ RIIIb (CD16b). These receptors bind to the Fc portion of the IgG antibody and are encoded by two different highly homologous genes in a cell type-specific manner. CD16b, also known as FCGR3b and FCG3b, is specifically expressed by neutrophils and stimulated eosinophils. CD16b is a low affinity receptor of immunoglobulin Fc γ region. CD16b binds composite or aggregated IgG and monomer IgG. CD16b could not mediate antibody-dependent cytotoxicity and phagocytosis.
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