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Description
Aflibercept Onestep ELISA KitProduct Specification Antigen Aflibercept Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Others Purification Protein A Stability & Storage 12 months from date of receipt reconstitution, 2 to 8'C as supplied. Kit Precision Intra assay: 3. 7% Inter assay: 4. 7% Sample type Cell culture supernatant; Serum; Plasma Assay type Sandwich (quantitative) Sensitivity 0. 134 ng mL Range 1. 56 ng mL 100 ng mL Recovery Cell culture
Product Specification
| Antigen | Aflibercept |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Others |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8'C as supplied. |
Kit
| Precision | Intra-assay: 3.7%； Inter-assay: 4.7% |
| Sample type | Cell culture supernatant; Serum; Plasma |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 0.134 ng/mL |
| Range | 1.56 ng/mL – 100 ng/mL |
| Recovery | Cell culture supernatant: 118% Serum: 112% Plasma: 95% |
| Assay time | 60 minutes |
| Species reactivity | Others |
Background
Aflibercept (marketed under brand names such as EYLEA® and ZALTRAP®) is an injectable prescription medicine classified as a VEGF (Vascular Endothelial Growth Factor) inhibitor. It functions as a recombinant fusion protein, essentially acting as a "VEGF trap." Its mechanism involves binding to VEGF-A and placental growth factor (PlGF) with high affinity. By doing so, it blocks their interaction with natural VEGF receptors. This inhibition prevents the growth of new, leaky blood vessels (angiogenesis) and decreases vascular permeability, which is a key factor in reducing fluid accumulation (edema). Aflibercept is primarily used in ophthalmology to treat neovascular (wet) Age-related Macular Degeneration (AMD), macular edema following Retinal Vein Occlusion (RVO), and Diabetic Macular Edema (DME). It is also used in oncology, in combination with chemotherapy, for certain types of metastatic colorectal cancer. The drug is administered directly into the eye (intravitreal injection) for retinal conditions and intravenously for cancer treatment. Its therapeutic effect helps to stabilize and often improve vision in eye diseases by controlling the abnormal blood vessel growth and leakage that cause damage to the retina.
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