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Description
PIN1 Recombinant Rabbit mAb (S-2731-43)Product Specification Host Rabbit Antigen PIN1 Synonyms Peptidyl prolyl cis trans isomerase NIMA interacting 1; Peptidyl prolyl cis trans isomerase Pin1 (PPIase Pin1); Rotamase Pin1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q13526 Clone Number S 2731 43 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample HEK 293, Jurkat, A549, HeLa, NIH 3T3, mouse heart, PC 12, rat brain, COS
Product Specification
| Host | Rabbit |
| Antigen | PIN1 |
| Synonyms | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl-prolyl cis-trans isomerase Pin1 (PPIase Pin1); Rotamase Pin1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q13526 |
| Clone Number | S-2731-43 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HEK-293, Jurkat, A549, HeLa, NIH/3T3, mouse heart, PC-12, rat brain, COS-7 |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt, Mk |
| ICC | 1:500 | Hu |
Background
PIN1 is a conserved 163-residue peptidyl-prolyl cis-trans isomerase composed of an N-terminal WW domain and a C-terminal catalytic PPIase domain, both recognizing pSer/Thr-Pro motifs; by selectively isomerizing these phosphorylated bonds it acts as a post-phosphorylation switch that reshapes the conformation, stability, localization and ubiquitination of hundreds of client proteins—ranging from p53 and cyclins to NF-κB and APP—thereby governing cell-cycle progression, transcription, immune signaling and neuronal homeostasis, while its frequent over-activation in cancer drives oncogenic pathways and its loss contributes to neurodegenerative diseases such as Alzheimer’s.
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4.8 ★★★★★
Based on 5 reviews
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Product Reviews
★★★★★ 5
Great Summer Bridge Activities for Students going into 4th Grade
Good for 3rd going into 4th grade summer activities.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 29, 2026
★★★★★ 5
Excellent Summer Resource for Kids!
Format: Paperback
I purchased the "Summer Bridge Activities 2nd to 3rd Grade Workbook" for my 8-year-old, and it has exceeded my expectations in every way. This comprehensive workbook is a fantastic tool to keep children engaged and learning during the summer break. My sibling is an elementary school teacher and introduced me to these books when my son was in Kindergarten and I honestly have not looked back. My LO loved a good challenge so we typically do multiple days to ensure we finish it in its entirety during the summer. I'm constantly recommending these books every summer as I have not yet found anything to replace it.
Content Quality:
The workbook covers all essential subjects: math, reading comprehension, writing, science, social studies, and even fitness. Each section is well-organized and filled with age-appropriate activities that challenge and entertain. The variety of exercises ensures that my child doesn't get bored, and the progressive difficulty helps build confidence.
Educational Value:
The math and reading comprehension sections are particularly strong, with clear explanations and plenty of practice problems. The writing prompts encourage creativity and critical thinking, while the science and social studies sections introduce interesting facts and concepts. I appreciate the inclusion of fitness activities, promoting a healthy lifestyle alongside academic learning.
Flash Cards:
The included flash cards are a wonderful bonus. They are durable, colorful, and perfect for quick review sessions. My child enjoys using them, and they make reinforcing concepts fun and interactive.
Ease of Use:
The workbook is user-friendly with clear instructions for both parents and kids. It's designed to be self-paced, which means my child can work independently or with minimal guidance. The answer key at the back is helpful for quick checks.
Engagement:
What sets this workbook apart is its ability to make learning enjoyable. The activities are engaging, and the themes are relevant and interesting. My child looks forward to workbook time each day, which is a huge win for any parent trying to prevent the summer slide.
Overall, the "Summer Bridge Activities 2nd to 3rd Grade Workbook" is an excellent investment in your child's education. It's thorough, fun, and well-designed to keep young minds sharp over the summer. I highly recommend it to any parent looking to provide a balanced and enriching educational experience during the school break.
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Reviewed in the United States on June 13, 2024
★★★★★ 5
Good quality for price
Format: Paperback
This was a good book for the summer. It has a variety of activities so my child didn't get bored. It also has some fun "outside" only ideas to get them up and moving. It was a good bridge book that she could (mostly) do independently. However, as they progress through it, parents should be there to help and reiterate different concepts. It was well worth the price and helped the transition go smoothly.
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Reviewed in the United States on November 12, 2025
★★★★★ 5
Perfect To Keep A Youngster's Mind Active Over The Summer
Format: Paperback
Simply put, this is a great activity book to help your child stay mentally active when out of school for the summer. It is not intended to be a full school curriculum, but instead a way to keep children mentally active during the summer break. We have a child leaving 2nd and heading to 3rd grade and were concerned about her skills being lost over the summer. While we do work with her to increase her skillset, we were more concerned about the atrophy that happens when not in school than jumping her ahead. It can be a bit tough for kids returning to school if they go 2-3 months with little book work, so we wanted to help keep her fresh but not fill her summer with full days of 'school' work.
This book is a solid mix of skills with some being easy and others more of stretch. The easy and stretch items will vary with the schooling your child gets and their abilities. I suspect most kids heading to third grade will find most of the work in this book at least a strong refresher and potentially help move them in some areas. This is setup to be a roughly 15 minute daily regime but we have enhanced it with some other work. We have math and science specific activity books as well as a reading workbook that we rotate into the mix. We also keep track of words she has a harder time spelling and use them make a 10 spelling word weekly review and test (review for 4 days and test on the fifth). Most of these topics are in the bridge activities book, but we felt a little extra attention would not hurt and some variety in what she is working on keeps things fresh. We do spelling, reading/writing and a couple 'pages' of work each weekday which comes out to about a 45-60 minute batch of work. The Summer Bridge Activities books is a constant in the mix with a page used almost every day and the other work rotated.
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Reviewed in the United States on July 5, 2017
★★★★★ 4
Great summer workbook!
Format: Paperback
So far an easy book compared to the Argo Summer Academy one that was too challenging. I don't like the way the pages are perforated they fall out of the book too easily. I feel like it is a good balance of keeping up skills already learned and softly introducing a little bit of challenge. I like how each day has math and reading. Easy to keep skills up with only 15 minutes of work a day.
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Reviewed in the United States on June 22, 2025
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