Pay in installments of $25.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 23 - Jul 28
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
IGFBP7 Recombinant Rabbit mAb (S-3091-44)Product Specification Host Rabbit Antigen IGFBP7 Synonyms Insulin like growth factor binding protein 7; IBP 7; IGF binding protein 7; IGFBP 7; IGFBP rP1; MAC25 protein; PGI2 stimulating factor; Prostacyclin stimulating factor; Tumor derived adhesion factor (TAF); MAC25; PSF Immunogen Synthetic Peptide Location Secreted Accession Q16270 Clone Number S 3091 44 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu Positive Sample
Product Specification
| Host | Rabbit |
| Antigen | IGFBP7 |
| Synonyms | Insulin-like growth factor-binding protein 7; IBP-7; IGF-binding protein 7; IGFBP-7; IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor (TAF); MAC25; PSF |
| Immunogen | Synthetic Peptide |
| Location | Secreted |
| Accession | Q16270 |
| Clone Number | S-3091-44 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu |
| Positive Sample | SW480, SK-OV-3 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| ICC | 1:100 | Hu |
Background
Insulin-like growth factor-binding protein 7 (IGFBP7), also known as MAC25 or prostacyclin-stimulating factor, is a secreted glycoprotein belonging to the IGFBP superfamily that uniquely exhibits low affinity for insulin-like growth factors (IGFs) compared to other family members, thereby functioning primarily through IGF-independent mechanisms to regulate critical cellular processes such as senescence, apoptosis, and angiogenesis. Originally identified as a tumor suppressor frequently downregulated or silenced via promoter hypermethylation in various malignancies including breast, colorectal, and prostate cancers, IGFBP7 exerts its anti-tumor effects by inhibiting the RAS-MAPK signaling pathway and disrupting endothelial cell tube formation, while also playing a pivotal physiological role in vascular biology by stimulating prostacyclin production and maintaining vascular tone. Beyond its oncological significance, emerging research highlights its involvement in metabolic regulation, kidney injury responses, and fibrotic diseases, positioning IGFBP7 not only as a promising diagnostic and prognostic biomarker but also as a potential therapeutic target for restoring normal cell cycle control and inhibiting pathological neovascularization.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy