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Description
Human MMP-9 ELISA KitProduct Specification Species Reactivity Human Theory This kit adopts double antibody sandwich enzyme linked immunosorbent detection technology. Specific anti human MMP 9 antibodies were pre coated on high affinity labeled plates. The standard substance, the sample to be tested and the biotinylated detection antibody are added to the well of the enzyme label plate, and after incubation, the MMP 9 present in the sample binds to the solid phase antibody
Product Specification
| Species Reactivity | Human | |||||||||||||||||||||||||||
| Theory | This kit adopts double antibody sandwich enzyme-linked immunosorbent detection technology. Specific anti-human MMP-9 antibodies were pre-coated on high affinity labeled plates. The standard substance, the sample to be tested and the biotinylated detection antibody are added to the well of the enzyme label plate, and after incubation, the MMP-9 present in the sample binds to the solid phase antibody and the detection antibody to form an immune complex. After washing to remove unbound material, horseradish peroxidase-labeled Streptavidin-HRP was added. After washing, a chromogenic substrate is added to protect the color from light. A stop solution was added to stop the reaction, and the absorbance value was measured at a wavelength of 450 nm (reference calibration wavelength of 540 nm or 570 nm). | |||||||||||||||||||||||||||
| Synonym | 92 kDa gelatinase, 92 kDa type IV collagenase, CLG4B, EC 3.4.24, EC 3.4.24.35, Gelatinase B, GELB, macrophage gelatinase, MANDP2, matrix metallopeptidase 9, matrix metalloproteinase 9, matrix metalloproteinase-9, MMP9, MMP-9, type V collagenase | |||||||||||||||||||||||||||
| Composition |
Please use within the expiration date of the kit
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| Background | Matrix metalloproteinases (MMPs), also known as matrixins, are members of the zinc-calcium-dependent proteolytic enzyme family, which can break down the extracellular matrix (ECM) and participate in the processing of various molecules in different subcellular environments. MMPs play important functions in numerous physiological processes, such as embryonic development, morphogenesis, reproduction, and tissue remodeling. Also involved in inflammation as well as autoimmune diseases such as arthritis, cancer and cardiovascular diseases. The amount of newly synthesized MMPs is mainly regulated at the transcriptional level, and the proteolytic activity of already existing MMPs is controlled not only by the activity of the zymogen, but also by the inhibition of enzyme activity by endogenous inhibitors, such as α2-macroglobulin, and tissue inhibitors of metalloproteinases (TIMPs). MMP-9 (also known as gelatinase B, 92 kDa type IV collagenase, 92 kDa gelatinase, type V collagenase) is secreted as a proglycosylation enzyme. Activation of the zymogen involves proteolytic removal of the N-terminal precursor region, resulting in the formation of an active enzyme of 82 kDa. Active human MMP-9 has 72% and 74% amino acid sequence homology with mouse and rat MMP-9, respectively. In addition to the zinc binding site, the catalytic domain contains three consecutive fibronectin type II homologous units that bind to gelatin. A proline-rich hinge region links the catalytic domain to the C-terminal heme-like domain. In vitro experiments, after treatment with 4-aminophenyl ethyl acetate (APMA), the enzymogen can not only produce active enzyme, but also produce a C-terminal truncated form with equivalent activity. MMP-9 can degrade components in ECM, especially with very high specificity for denatured collagen (gelatin). MMP-9 also cleaves collagen types III, IV, V, XI, as well as elastin, nestin-1, and vitronectin. MMP-9 can also cleave a variety of chemokines and growth factors (e.g., IL-1β, CXCL8/IL-8, CXCL7, CXCL4, CXCL1, LatentTGF-β, membrane-bound TNF-α, VEGF, and FGFbasic), beta-amyloid, substance P, myelin basic protein. This action may increase or decrease the biological activity of these soluble factors, and may also cause them to be released from association with the ECM. MMP-9 can also trigger signaling pathways through various membrane proteins or induce them to fall off the cell membrane to inhibit signaling pathways (E.g. CD44, E-cadherin, integrin, ICAM-1 and IL-2Rα). MMP-9 is produced by a variety of normal and transformed cells, including neutrophils, monocytes, macrophages, astrocytes, fibroblasts, osteoclasts, chondrocytes, keratinocytes, endothelial cells, and epithelial cells. It affects physiological and pathological angiogenesis and vascular remodeling. Activated neutrophils release the MMP-9 precursor and do not bind to TIMP-1, allowing pro-angiogenic FGF-2 to be released from the ECM. The complex of MMP-9 and TIMP-1 failed to induce the release of FGF-2. Neutrophil-derived MMP-9 can exacerbate the inflammatory response, inducing the release of additional neutrophil MMP-9 by the production of collagen-derived polypeptides. MMP-9 also plays an important role in bone formation and remodeling, methamphetamine-induced behavioral sensitization and response, regulation of neuronal synaptic remodeling, trophoblast invasion during implantation, and activation of serine protease inhibitor α1. MMP-9-mediated shedding of adhesion molecules also has a direct effect on tumor cell invasion. Circulating levels of MMP-9 are elevated in many inflammatory disorders, including the formation of intraluminal thrombus, atherosclerosis, Crohn's disease, hepatitis C virus infection, colorectal cancer, and Duchenne muscular dystrophy. The ratio of MMP-9 to TIMP-1 was elevated in multiple sclerosis sera and cystic fibrous sputum but decreased in cytomegalovirus-infected sera. The level of free MMP-9 and the level of MMP-9 and lipocalin-2/NGAL complex were elevated in the urine of patients with ovarian cancer and patients with uterine urethral tract infection, respectively. |
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| General Notes | 1. Please use the kit within the validity period. 2. The components of different kits and different batch kits cannot be mixed. 3. If the sample value is greater than the highest value of the standard curve, the sample should be diluted with diluent (1 ×) and re-tested; If the cell culture supernatant sample needs to be distributed and diluted, cell culture medium can be used for other intermediate dilutions except dilution with diluent in the last step. 4. Differences in test results can be caused by a variety of factors, including the operation of the experimenter, the use of the pipette, the plate washing technique, the reaction time or temperature, the storage of the kit, etc. 5. The terminating solution in the kit is an acidic solution. Please protect your glasses, hands, face and clothes when using it. 6. For scientific research only, not for in vitro diagnosis. |
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| Storage Temp. | Kit unopened, stored at 2-8 °C. | |||||||||||||||||||||||||||
| Test Range | 31.3pg/mL-2000pg/mL |
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4.1 ★★★★★
Based on 14 reviews
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Product Reviews
★★★★★ 5
A Lovely and Useful Gift
Color: Cloud White, Material Type: Paper, PU
I bought this SONGMICS jewelry organizer box as a gift and it was a great choice. The design is beautiful and it keeps jewelry well organized. It’s compact and perfect for travel or everyday use. The person I gave it to loved it and uses it all the time.
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Reviewed in the United States on March 8, 2026
★★★★★ 5
Small and cute!
Color: Cloud White, Material Type: Paper, PU
Its perfect!
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Reviewed in the United States on May 25, 2026
★★★★★ 5
Small But Mighty — The Best Travel Jewelry Case I’ve Ever Used
Color: Glitter White
This Hatori travel jewelry box is honestly the best little jewelry organizer I’ve ever owned. I don’t know how it works its magic, but it somehow fits so much jewelry and still looks tiny and compact. Go figure.
Size & Portability:
It’s the perfect size—small enough to toss into a suitcase, carry-on, or even a purse, but big enough to hold everything I need for a trip. Lightweight, sturdy, and it takes up almost no space.
Storage Layout:
The double-layer design is genius.
Bottom: 7 ring rolls + 3 removable compartments (I love that I can move them around depending on what I’m packing).
Top: 5 hooks and an elastic pocket to keep necklaces from tangling—YES, it actually works.
Everything stays in place, nothing gets tangled, and it looks beautifully organized when you open it. A travel miracle.
Quality:
The glittery white PU leather exterior is sturdy and cute, and the interior is lined with soft velvet that protects everything. The clasp is easy to use and feels secure—no accidental openings in your suitcase.
Why I Love It:
It’s compact, durable, organized, and honestly just adorable. Perfect for travel, but also great for keeping your everyday jewelry together in a drawer.
If you travel at all—or just like your jewelry organized—this little box is worth every penny. It packs a punch for its size.
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Reviewed in the United States on November 27, 2025
★★★★★ 5
Great box for traveling or your safe!
Color: Black
The Travel Jewelry Box is a must-have accessory for anyone who loves to accessorize on the go. This compact yet versatile organizer is the perfect solution for keeping your favorite jewelry safe, secure, and tangle-free while you travel.
Let's start with the design. The Travel Jewelry Box is intelligently crafted to maximize space without sacrificing functionality. Despite its compact size, it features multiple compartments, pockets, and hooks to accommodate a variety of jewelry pieces. From earrings and rings to necklaces and bracelets, there's a dedicated spot for everything, ensuring that your jewelry stays organized and protected during transit.
Durability is another standout feature of this jewelry box. Constructed from high-quality materials like faux leather or sturdy fabric, it's built to withstand the wear and tear of travel. The exterior provides a layer of protection against bumps and scratches, while the interior is lined with soft velvet or plush fabric to prevent your jewelry from getting damaged.
One of the things I love most about the Travel Jewelry Box is its versatility. Whether you're jet-setting across the globe or simply heading out for a weekend getaway, this compact organizer is the perfect companion. It easily fits into your carry-on luggage, purse, or backpack, ensuring that your precious jewelry is always within reach. And with its sleek and stylish design, it adds a touch of elegance to your travel ensemble.
But perhaps the best part about the Travel Jewelry Box is its practicality. It's designed with the traveler in mind, featuring thoughtful details like a secure zipper closure, removable compartments, and a compact size that fits easily into any travel bag. No more digging through tangled necklaces or searching for lost earrings – with this jewelry box, everything has its place, making it easy to find and access your favorite pieces whenever you need them.
In conclusion, the Travel Jewelry Box is a game-changer for anyone who wants to travel in style without sacrificing the safety and organization of their jewelry. With its smart design, durability, versatility, and practicality, it's a must-have accessory for jet-setters, weekend warriors, and anyone in between. Trust me, once you experience the convenience of the Travel Jewelry Box, you'll wonder how you ever traveled without it!
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Reviewed in the United States on May 29, 2024
★★★★★ 4
Great travel jewelry case
Color: Black
Great colors. Good size. Easy to pack and carry. Fits a good amount of jewelry. It’s decent quality. I know there is better out there but for the value it’s great. It snaps close and I haven’t had mine accidentally come open at all. The inside is soft. My necklaces did get a little tangled inside but not too bad. I could have put them in there better. Very nice though.
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Reviewed in the United States on January 21, 2025