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Description
LC3B Recombinant Rabbit mAb (S-477-89)Product Specification Host Rabbit Antigen LC3B Synonyms Microtubule associated proteins 1A 1B light chain 3B, Autophagy related protein LC3 B, Autophagy related ubiquitin like modifier LC3 B, MAP1 light chain 3 like protein 2, MAP1A MAP1B light chain 3 B (MAP1A MAP1B LC3 B), Microtubule associated protein 1 light chain 3 beta, MAP1LC3B, MAP1ALC3 Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton Accession Q9GZQ8 Clone Number S 477 89
Product Specification
| Host | Rabbit |
| Antigen | LC3B |
| Synonyms | Microtubule-associated proteins 1A/1B light chain 3B, Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, MAP1 light chain 3-like protein 2, MAP1A/MAP1B light chain 3 B (MAP1A/MAP1B LC3 B), Microtubule-associated protein 1 light chain 3 beta, MAP1LC3B, MAP1ALC3 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton |
| Accession | Q9GZQ8 |
| Clone Number | S-477-89 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied. |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC | 1:1000 |
Background
LC3 is a central protein in the autophagy pathway where it functions in autophagy substrate selection and autophagosome biogenesis. LC3 is the most widely used marker of autophagosomes. Newly synthesized LC3's C-terminus is hydrolyzed by a cysteine protease called ATG4B exposing Gly120, termed LC3-I. LC3-I, through a series of ubiquitin-like reactions involving enzymes ATG7, ATG3, and ATG12-ATG5-ATG16, becomes conjugated to the head group of the lipid phosphatidylethanolamine. The lipid modified form of LC3, referred to as LC3-II, is believed to be involved in autophagosome membrane expansion and fusion events.
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