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Description
EpCAM Recombinant Rabbit mAb (SDT-078-128)Product Specification Host Rabbit Antigen EpCAM Synonyms Epithelial cell adhesion molecule; Ep CAM; Adenocarcinoma associated antigen; Cell surface glycoprotein Trop 1; Epithelial cell surface antigen; Epithelial glycoprotein (EGP); Epithelial glycoprotein 314 (EGP314; hEGP314); CD326; GA733 2; M1S2; M4S1; MIC18; TACSTD1; TROP1 Immunogen Synthetic Peptide Location Cell membrane Accession P16422 Clone Number SDT 078 128 Antibody Type Recombinant mAb
Product Specification
| Host | Rabbit |
| Antigen | EpCAM |
| Synonyms | Epithelial cell adhesion molecule; Ep-CAM; Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein (EGP); Epithelial glycoprotein 314 (EGP314; hEGP314); CD326; GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P16422 |
| Clone Number | SDT-078-128 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HT-29, A431, HCT 116, T-47D, mouse colon, rat colon |
| Predicted Reactivity | Pg, Bv |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:2000 | Hu, Ms, Rt |
| IHC-P | 1:2000 | Hu, Ms, Rt |
| ICC | 1:250 | Hu |
Background
EpCAM (epithelial cell adhesion molecule, CD326) is a 35–40 kDa type-I transmembrane glycoprotein expressed on most epithelia, where it first assembles into cis-dimers that further cluster into tetramers to support homotypic cell–cell contacts, and then—through sequential proteolytic cleavage—releases its intracellular domain (EpICD) that partners with β-catenin, FHL2 and LEF1 to enter the nucleus and drive Wnt-dependent transcription of genes controlling proliferation, stemness and epithelial-to-mesenchymal transition, thereby functioning not merely as an adhesion molecule but as a dynamic signaling hub that is highly up-regulated in most carcinomas, marks circulating tumor and cancer stem cells, and serves as both a prognostic biomarker and a therapeutic target while mutations that truncate or mis-localize the protein underlie the severe congenital diarrhea disorder tufting enteropathy.
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Exchange/Return Notes
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