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Description
Carbonic Anhydrase IX/CA9 His Tag Protein, MouseProduct Specification Species Mouse Antigen Carbonic Anhydrase IX CA9 Synonyms EC: 4. 2. 1. 1Renal cell carcinoma associated antigen G250P54 58NCarbonic Anhydrase 9RCC Associated Protein G250Carbonate Dehydratase IXCarbonic DehydrataseCA IXCAIXPMW1MNEC 4. 2. 1. 1G250Membrane antigen MNRCC associated antigen G250 Accession Q8VHB5 Amino Acid Sequence Gln32 Asp390, with C terminal 8*His
Product Specification
| Species | Mouse |
| Antigen | Carbonic Anhydrase IX/CA9 |
| Synonyms | EC:4.2.1.1，Renal cell carcinoma-associated antigen G250，P54/58N，Carbonic Anhydrase 9，RCC-Associated Protein G250，Carbonate Dehydratase IX，Carbonic Dehydratase，CA-IX，CAIX，PMW1，MN，EC 4.2.1.1，G250，Membrane antigen MN，RCC-associated antigen G250 |
| Accession | Q8VHB5 |
| Amino Acid Sequence |
Gln32-Asp390, with C-terminal 8*His QPQGLSGMQGEPSLGDSSSGEDELGVDVLPSEEDAPEEADPPDGEDPPEVNSEDRMEESLGLEDLSTPEAPEHSQGSHGDEKGGGHSHWSYGGTLLWPQVSPACAGRFQSPVDIRLERTAFCRTLQPLELLGYELQPLPELSLSNNGHTVQLTLPPGLKMALGPGQEYRALQLHLHWGTSDHPGSEHTVNGHRFPAEIHVVHLSTAFSELHEALGRPGGLAVLAAFLQESPEENSAYEQLLSHLEEISEEGSKIEIPGLDVSALLPSDLSRYYRYEGSLTTPPCSQGVIWTVFNETVKLSAKQLHTLSVSLWGPRDSRLQLNFRATQPLNGRTIEASFPAAEDSSPEPVHVNSCFTAGDGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 43-55kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles. |
| Reference |
1.Supuran CT. Carbonic anhydrases: noveltherapeutic applications for inhibitors and activators. Nat Rev Drug Discov2008;7:168–81. 2.McDonald PC, Swayampakula M, Dedhar S..Coordinated regulation of metabolic transporters and migration/invasion bycarbonic anhydrase IX. Metabolites 2018;8:E20. |
Background
The CAIX works as a dimeric molecule composed of two monomeric proteins liked with a disulfide bond between cysteine residues of the two CAIX monomers, while the structure of CAXII is stabilized by 19 hydrogen-bonded interactions in the dimer interface. Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide into bicarbonate with a release of the proton.CAIX functions with bicarbonate transporters (including electroneutral bicarbonate transporter NBCn1 (SLC4A7)) to bring in HCO3- produced in a CAIX-mediated hydration reaction of CO2, and amino acid transporters (including the large neutral amino acid transporter 1 (LAT1) and CD98 heavy chain (CD98hc)) to transport in essential amino acids and glutamine (via interaction with glutamine transporter SLC1A5 and sodium-coupled neutral amino acid transporter 2 (SNAT2) facilitating the uptake of aminoacid by SLC1A5), which cancer cells employ as an alternative metabolic energy source and biosynthetic precursor. CAIX also creates unique interactions with collagen- and laminin-binding integrins at the leading edge of migrating cells.
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