SKU: 56672274244

Carbonic Anhydrase IX/CA9 His Tag Protein, Mouse

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Description

Carbonic Anhydrase IX/CA9 His Tag Protein, MouseProduct Specification Species Mouse Antigen Carbonic Anhydrase IX CA9 Synonyms EC: 4. 2. 1. 1Renal cell carcinoma associated antigen G250P54 58NCarbonic Anhydrase 9RCC Associated Protein G250Carbonate Dehydratase IXCarbonic DehydrataseCA IXCAIXPMW1MNEC 4. 2. 1. 1G250Membrane antigen MNRCC associated antigen G250 Accession Q8VHB5 Amino Acid Sequence Gln32 Asp390, with C terminal 8*His

Product Specification


Species Mouse
Antigen Carbonic Anhydrase IX/CA9
Synonyms EC:4.2.1.1,Renal cell carcinoma-associated antigen G250,P54/58N,Carbonic Anhydrase 9,RCC-Associated Protein G250,Carbonate Dehydratase IX,Carbonic Dehydratase,CA-IX,CAIX,PMW1,MN,EC 4.2.1.1,G250,Membrane antigen MN,RCC-associated antigen G250
Accession Q8VHB5
Amino Acid Sequence

Gln32-Asp390, with C-terminal 8*His

QPQGLSGMQGEPSLGDSSSGEDELGVDVLPSEEDAPEEADPPDGEDPPEVNSEDRMEESLGLEDLSTPEAPEHSQGSHGDEKGGGHSHWSYGGTLLWPQVSPACAGRFQSPVDIRLERTAFCRTLQPLELLGYELQPLPELSLSNNGHTVQLTLPPGLKMALGPGQEYRALQLHLHWGTSDHPGSEHTVNGHRFPAEIHVVHLSTAFSELHEALGRPGGLAVLAAFLQESPEENSAYEQLLSHLEEISEEGSKIEIPGLDVSALLPSDLSRYYRYEGSLTTPPCSQGVIWTVFNETVKLSAKQLHTLSVSLWGPRDSRLQLNFRATQPLNGRTIEASFPAAEDSSPEPVHVNSCFTAGDGGGSHHHHHHHH

Expression System HEK293
Molecular Weight 43-55kDa (Reducing)
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

·12 months from date of receipt, -20 to -70 °C as supplied. 

·1 month, 2 to 8 °C under sterile conditions after reconstitution.  

·Please avoid repeated freeze-thaw cycles.

Reference

1.Supuran CT. Carbonic anhydrases: noveltherapeutic applications for inhibitors and activators. Nat Rev Drug Discov2008;7:168–81.

2.McDonald PC, Swayampakula M, Dedhar S..Coordinated regulation of metabolic transporters and migration/invasion bycarbonic anhydrase IX. Metabolites 2018;8:E20.

Background

The CAIX works as a dimeric molecule composed of two monomeric proteins liked with a disulfide bond between cysteine residues of the two CAIX monomers, while the structure of CAXII is stabilized by 19 hydrogen-bonded interactions in the dimer interface. Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide into bicarbonate with a release of the proton.CAIX functions with bicarbonate transporters (including electroneutral bicarbonate transporter NBCn1 (SLC4A7)) to bring in HCO3- produced in a CAIX-mediated hydration reaction of CO2, and amino acid transporters (including the large neutral amino acid transporter 1 (LAT1) and CD98 heavy chain (CD98hc)) to transport in essential amino acids and glutamine (via interaction with glutamine transporter SLC1A5 and sodium-coupled neutral amino acid transporter 2 (SNAT2) facilitating the uptake of aminoacid by SLC1A5), which cancer cells employ as an alternative metabolic energy source and biosynthetic precursor. CAIX also creates unique interactions with collagen- and laminin-binding integrins at the leading edge of migrating cells.

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SKU: 56672274244

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Kelly
Boise, US
★★★★★ 5
Great
Flavor Name: Bacon & Chicken, Size: X-Large
My dogs love to chew these and they are long lasting
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 23, 2026
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Egward
Lake Worth, US
★★★★★ 5
👍
Flavor Name: Chicken, Size: Medium, Flavor Name: Chicken, Size: Medium
Chicken flavor mild kinda just taste spicy plastic but flaverfade quickly. It off-white more than white but it look mostly like picture otherwise. hard and durable but nit hurt teeth. Medium suggested for average human.
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Reviewed in the United States on May 20, 2026
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Matt S.
Whiting, US
★★★★★ 5
Long lasting
Flavor Name: Bacon, Size: Medium
Great dog toy, long lasting
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Reviewed in the United States on May 11, 2026
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Marie Phillips
San Leandro, US
★★★★★ 4
Tough Chewer Approved but Not a Forever Toy
Flavor Name: Original, Size: X-Large
I do like this toy for what it is meant to do. It is definitely built for strong chewers and holds up way better than softer toys that get destroyed in minutes. The texture keeps dogs interested and gives them something to really work on, which helps with boredom and can support dental cleaning through chewing. It is one of those “finally something that lasts a bit” kind of toys for heavy chewers. That said, it is not something you just toss in and forget about forever. Like most hard nylon toys, it will wear down over time and should be checked regularly for rough edges or changes in shape. Some dogs will also go through it faster depending on how intense their chewing style is, so replacement will eventually be needed. Girl, this is one of those “it survives the chaos better than most, but you still need to keep an eye on it” situations.
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Reviewed in the United States on May 4, 2026
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Customer Review
West Palm Beach, US
★★★★★ 5
The Remote Worker's Savior
Flavor Name: Bacon, Size: Medium
If you're like me, trying to balance deadlines and Zoom meetings while your furry co-worker incessantly nudges you for attention, then listen up because I've found the ultimate secret weapon: the Nylabone Chew Dog Toy. Trust me, it's a game-changer that will keep your dog busy and your productivity soaring. Picture this: you're knee-deep in spreadsheets, buried in emails, and your dog is bouncing around like a furry tornado, demanding playtime. Enter the Nylabone Power Chew, the superhero of dog toys that saves the day. Its durability is off the charts, my friends. It can withstand a full day of canine chewing fury, leaving your furniture unscathed and your dog blissfully entertained. But here's where the magic happens. This toy isn't just tough; it's also infused with a bacon flavor that sends your dog's taste buds into a frenzy. It's like having a bacon-scented office right in your home! As your dog sinks their teeth into this baconlicious wonder, their focus shifts from your keyboard to their newfound chewy delight. Suddenly, the tug-of-war with your important documents becomes a distant memory. Now, let's talk about the beauty of this toy's distraction power. With the Nylabone Power Chew in play, your dog becomes engrossed in their chewy mission. They're occupied, happily gnawing away, while you conquer your work tasks like a true champion. It's like having a personal assistant who doesn't interrupt you every five minutes with a squeaky toy demand. But don't be fooled by its functionality; the Nylabone Power Chew brings more than just peace and quiet. It brings laughter and joy to your work-from-home routine. Watching your pup go to town on this bacon-infused wonder is like having a built-in comedy show right in your home office. It's the perfect stress relief during those never-ending conference calls. And let's not forget the Nylabone brand's commitment to quality. This chew toy is built to last, crafted with non-toxic materials that keep your beloved furry friend safe and sound. It's like having a reliable coworker who never lets you down. So, my fellow remote workers, if you're desperate for a productivity boost and a furry coworker who won't pester you all day long, the Nylabone Chew Dog Toy is your secret weapon. It's a dog toy miracle that keeps your pup happily occupied while you conquer the work world. Say goodbye to interruptions and hello to a harmonious work-from-home environment. Trust me, you'll wonder how you ever survived without it!
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Reviewed in the United States on May 25, 2023

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