SKU: 59863304929

Mouse Anti-Human TCR α/β Antibody (S-R686)

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Description

Mouse Anti-Human TCR α/β Antibody (S-R686)Product Specification Host Mouse Antigen TCR Synonyms TCR; TCR Location Cell membrane Accession P01848 P01850 Clone Number S R686 Antibody Type Mouse mAb Application FCM Reactivity Hu Positive Sample Human PBMC Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied. Dilution application dilution species FCM 1: 200 Hu

Product Specification


Host Mouse
Antigen TCR α/β
Synonyms α/β TCR; TCR α/β
Location Cell membrane
Accession P01848、 P01850
Clone Number S-R686
Antibody Type Mouse mAb
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4

Stability & Storage 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

Dilution


application dilution species
FCM 1:200 Hu

Background

The T cell receptor (TCR) α and β proteins are essential components of the αβ T cell receptor, a heterodimeric surface protein expressed on T lymphocytes that recognizes antigenic peptides presented by major histocompatibility complex (MHC) molecules. The TCR α chain is encoded by the TRAC (T cell receptor alpha constant) and TRAV (T cell receptor alpha variable) genes, while the TCR β chain is encoded by the TRBC (T cell receptor beta constant) and TRBV (T cell receptor beta variable) genes, along with diversity (TRBD) and joining (TRBJ) segments, enabling extensive combinatorial diversity. Structurally, both chains consist of a variable (V) domain responsible for antigen recognition and a constant (C) domain that anchors the receptor to the cell membrane. The TCR αβ heterodimer associates with the CD3 complex (CD3γε, CD3δε, and CD247 ζζ) to form a functional TCR-CD3 signaling unit, which transmits activation signals upon peptide-MHC engagement. TCR β undergoes V(D)J recombination during thymic development, contributing to the receptor's antigen specificity, whereas TCR α lacks a D segment but still undergoes recombination for diversity. Mutations or dysregulation in TCR α/β genes can lead to immune disorders, including T cell malignancies and autoimmune diseases. TCR αβ T cells are critical for adaptive immunity, mediating responses against infections, tumors, and self-antigens in autoimmune conditions.

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SKU: 59863304929

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Tony Johnson
Chelsea, US
★★★★★ 5
Great quality!
Color: Silver-Blue
Got this for my husband for Christmas and he loves it. It looks really good on him and you can tell it’s great quality by the look and weight.
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Reviewed in the United States on May 21, 2026
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Yasar R
Draper, US
★★★★★ 5
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Color: Black
Amazing piece, not really a watch guy, but this watch is beautiful
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Reviewed in the United States on April 28, 2026
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Great monitor!
New York, US
★★★★★ 5
Everyday watch
Color: Silver-Blue
Durable and solid and looks really clean
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Reviewed in the United States on April 24, 2026
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Daniel Kim
Draper, US
★★★★★ 5
Well made
Color: Black
Excellent watch. Fits well. The color is smooth. Would recommend
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Reviewed in the United States on April 29, 2026
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Bella Nyamadi
Dallas, US
★★★★★ 4
The watch is beautiful
Color: Two Tone Green
My husband loved it I’m giving it 4 stars because they send me the wrong color. Otherwise, it looked great and definitely worth the price.
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Reviewed in the United States on December 28, 2025

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