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Description
Rat Anti-Mouse CD226 Antibody (S-R625)Product Specification Host Rat Antigen Mouse CD226 Synonyms CD226 antigen; Platelet and T cell activation antigen 1; Pta1 Location Cell membrane Accession Q8K4F0 Clone Number S R625 Antibody Type Rat mAb Isotype IgG2b,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date
Product Specification
| Host | Rat |
| Antigen | Mouse CD226 |
| Synonyms | CD226 antigen; Platelet and T-cell activation antigen 1; Pta1 |
| Location | Cell membrane |
| Accession | Q8K4F0 |
| Clone Number | S-R625 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Ms |
Background
CD226, also known as DNAM-1, is a type I transmembrane protein belonging to the immunoglobulin superfamily and is widely expressed on the surface of immune cells, including T cells, natural killer (NK) cells, and B cells. It plays a crucial role in immune regulation by interacting with its ligands, CD155 and CD112. CD226 enhances immune cell adhesion, cytotoxic activity, and cytokine secretion upon activation. It is particularly important in antitumor immunity, where it competes with TIGIT and CD96 for ligand binding, thereby promoting the antitumor activity of immune cells. However, its function can be inhibited by the high-affinity binding of TIGIT in the tumor microenvironment. Additionally, CD226 is involved in modulating the function of regulatory T cells (Tregs), influencing immune tolerance and autoimmune responses.
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