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Description
LAIR1 Recombinant Rabbit mAb (S-285-2)Product Specification Host Rabbit Antigen LAIR1 Synonyms Leukocyte associated immunoglobulin like receptor 1, LAIR 1, hLAIR1, CD305 Immunogen Recombinant Protein Location Cell membrane Accession Q6GTX8 Clone Number S 285 2 Antibody Type Rabbit mAb Application WB, IHC P, ICC, FCM, IP Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03%
Product Specification
| Host | Rabbit |
| Antigen | LAIR1 |
| Synonyms | Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, hLAIR1, CD305 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q6GTX8 |
| Clone Number | S-285-2 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, FCM, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IP | 1:50 | null |
| IHC | 1:500 | null |
| ICC | 1:500 | null |
| FCM | 1:500 | null |
Background
Leukocyte-associated immunoglobulin-like receptor 1 is a protein that in humans is encoded by the LAIR1 gene [PMID: 9285412]. LAIR1 has also been designated as CD305 (cluster of differentiation 305). LAIR-1 is a 32 kDa transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell-mediated cytotoxicity [PMID: 9285412].
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