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Description
Prolactin R/PRLR His Tag Protein, HumanProduct Specification Species Human Synonyms Prolactin R, PRLR, PRL R Accession P16471 Amino Acid Sequence Gln25 Asp234, with C terminal 8*His QLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDGGGSHHHHHHHH Expression System HEK293 Molecular Weight 32 36kDa Purity >95% by SDS PAGE Endotoxin <0.
Product Specification
| Species | Human |
| Synonyms | Prolactin R, PRLR, PRL-R |
| Accession | P16471 |
| Amino Acid Sequence | Gln25-Asp234, with C-terminal 8*His QLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 32-36kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Bole-Feysot C. et al. (1998) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev. 19(3): 225-268. |
Background
Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-III domains. Knockout prolactin receptor gene (PRL-R) mice are animal models for prolactinomas and PRL acts via autocrine/paracrine inhibiting lactotroph proliferation. Recently, variants of the PRL-R were identified in prolactinoma patients and their frequency was higher compared to individuals from the genomic database. As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. The PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.
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4.1 ★★★★★
Based on 7 reviews
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Product Reviews
★★★★★ 5
Great natural product
Size: 6 Fl Oz (Pack of 1)
I use this product for surfing and most of the natural sunscreens end up burning my eyes. This one does not run or rub off. After trying a bunch of other brands this has been my go to for the last couple of years.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 30, 2024
★★★★★ 5
Healthy Sunscreen
Size: 6 Fl Oz (Pack of 1)
Really great sunscreen without the harmful chemicals. Takes a bit longer to rub in since it sits on top of your skin vs. getting absorbed.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 15, 2023
★★★★★ 3
Too thick and hard to spread
Size: 6 Fl Oz (Pack of 1)
The lotion is so thick it takes forever for me to try to rub in and then your skin is left looking all white
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 11, 2020
★★★★★ 5
Best sunscreen on market
Size: 6 Fl Oz (Pack of 1)
Forget using carcinogenic chemicals. Use zinc and titanium to form a physical block. This stuff is of the best. Period.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 23, 2024
★★★★★ 5
Good Mineral Sunscreen
Size: 6 Fl Oz (Pack of 1)
Yes, it leaves a white cast, but it isn’t as thick and sticky as most out there. Very few ingredients makes me happy. I’ve tried mineral sunscreens with all zinc and they feel smothering, and like velvet everything sticks to the face. This one, with smaller amounts of zinc and titanium is better. It will pill if you use too much and rub too vigorously.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 13, 2023
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