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Description
FYN Recombinant Rabbit mAb (S-2157-52)Product Specification Host Rabbit Antigen FYN Synonyms Tyrosine protein kinase Fyn; Proto oncogene Syn; Proto oncogene c Fyn; Src like kinase (SLK); p59 Fyn Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Cell membrane Accession P06241 Clone Number S 2157 52 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample Raji, Ramos, HeLa, RAW264. 7, rat brain Purification Protein A Concentration 0. 5 mg
Product Specification
| Host | Rabbit |
| Antigen | FYN |
| Synonyms | Tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase (SLK); p59-Fyn |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Cell membrane |
| Accession | P06241 |
| Clone Number | S-2157-52 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Raji, Ramos, HeLa, RAW264.7, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:250 | Hu, Ms, Rt |
Background
FYN protein, also known as p59-FYN, SLK, or SYN, is a 59 kDa protein composed of 537 amino acids, encoded by the FYN gene located on chromosome 6q21. It is a member of the Src family of non-receptor tyrosine kinases and is primarily localized to the cytoplasmic leaflet of the plasma membrane. FYN plays crucial roles in various biological processes, including cell growth, survival, adhesion, cytoskeletal remodeling, and immune response. In the nervous system, it is involved in synaptic transmission, axon guidance, and neuronal differentiation. FYN also participates in T-cell receptor signaling pathways, regulating T-cell differentiation and proliferation. Additionally, it has been implicated in cancer progression due to its involvement in cell cycle regulation and its potential as a proto-oncogene.
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