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Description
Her4 His Tag Protein, HumanProduct Specification Species Human Synonyms Her4, ERBB4, 4ICD, MGC138404, p180erbB4 Accession Q15303 Amino Acid Sequence Gln26 Pro651, with C terminal 10*His
Product Specification
| Species | Human |
| Synonyms | Her4, ERBB4, 4ICD, MGC138404, p180erbB4 |
| Accession | Q15303 |
| Amino Acid Sequence | Gln26-Pro651, with C-terminal 10*His QSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 87-101kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Segers V F M. et al. (2020) The role of ErbB4 in cancer. Cell Oncol. 43: 335-352. 2、Xu J. et al. (2018) ERBB4 promotes the proliferation of gastric cancer cells via the PI3K/Akt signaling pathway. Oncol Rep 39: 2892-2898. |
Background
HER4, also known as ErbB4, is a member of epidermal growth factor receptor (EGFR) or ErbB family. The HER4 gene is localized on chromosome 2q33.3–34. HER4 is necessary for normal development of body systems including heart, nervous system, and mammary gland. HER4 is commonly expressed in many human tissues, both adult and fetal. EGFR/ErbB1/HER1, ErbB2/HER2, ErbB3/HER3, and ErbB4/HER4 are members of this receptor tyrosine kinase family. HER4 is the only member of this family of receptors with growth inhibiting properties. HER4 can activate related genes in the nucleus when combined with epidermal growth factor (EGF), promoting cell division and proliferation. It is activated through ligand binding and activates MAPKs and PI3K/AKT pathways. Her4 promotes glycolysis, glutaminolysis, mitochondrial biogenesis & OXPHOS through c-Myc-dependent signaling axis in cancer. The Her4-mediated metabolic reprogramming may in part cooperate to promote tumorigenesis in certain cancers.
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4.0 ★★★★★
Based on 26 reviews
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Product Reviews
★★★★★ 5
Pleased Customer!
Size: 42, Color: Red With Black Strip
Perfect fit!
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Reviewed in the United States on February 6, 2026
★★★★★ 4
Reasonable quality, slightly small, definitely unhemmed
Size: 42, Color: White With Black Strip, Size: 42, Color: White With Black Strip
If these pants are the right look for what you want/need, they're a reasonably good quality option. But that said, in practice these looked a little "cheesy" with the black stripe. I can't say for sure that's a result of how the product is made/how it looks, but I just couldn't see myself wearing them. That's assuming I could wear them... In terms of fit, they were slightly small in the waist for both pairs I ordered.
I'm not sure what I thought they meant when I read that they were unhemmed, but for those looking for pants to take out of the box and wear... these aren't for you. The ankles are not "finished" and require hemming to make them look acceptable. (This was my fault, so I didn't count off for this)
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Reviewed in the United States on July 8, 2021
★★★★★ 3
They stand out, and are flashy, but sizing is complicated.
Size: 34, Color: Black With White Strip, Size: 34, Color: Black With White Strip
High-quality pants and flashy. The stripe adds a lot of attention for reasons both good and bad.
The materials they were made are excellent quality. Pants are thick, but not too thick, and are lightweight, guaranteeing easy movement. Comfortable - could wear these all day.
I do love their appearance. They made me feel like a million bucks. :)
The only problem is sizing and fit. I normally wear size 34 for waist in jeans and dress pants like these, but the 34 I got didn't fit at all - too tight. So, I ordered a 36, and it fit, but barely. When I sat down, there was too much tightness in my "masculine area". I also ordered a 38, and, well, they were just too big - practically hung off me.
A 37 would probably work for me in these, but they don't offer such a size. I have to return the 34 and 38. Will keep the 36, see if I can have it altered in some way.
Length was fine. Being 1.86 meters, often the length in these pants is a little on the short side.
In the photo, I'm wearing size 36 and the black pair with the gold stripe, which is actually more of a flashy yellow. I liked how I looked in them, but they were a little too tight at times, the belt wasn't even necessary. It enhanced the outfit though, don't you think.
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Reviewed in the United States on July 20, 2025
★★★★★ 5
Good as a standard "Tuxedo" pants
Size: 42, Color: Black With Red Strip
Red Striping could be wider. These are good as a standard "Tuxedo" pants but if you are looking more fore a "Security Guard" style pants the striping needs to be wider.
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Reviewed in the United States on April 18, 2025
★★★★★ 5
Runs small in the waist
Size: 34, Color: Black With Black Strip
These are good pants, but as other reviewers have noted, they tend to run small. Order one size up from the size you normally order. I'm a 34 inch waist, and I ordered the 34. They were tight, and I had to have them let out. I may order another pair, and if so, I'll order the 36.
Don't be vain. Be smart.
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Reviewed in the United States on April 6, 2015
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