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Description
TfR/CD71 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms CD71, TFRC, TFR, sTfR, TfR1, Trfr, T9, p90 Accession A0A2K5X958 Amino Acid Sequence Cys89 Phe760, with N terminal 10*His
Product Specification
| Species | Cynomolgus |
| Synonyms | CD71, TFRC, TFR, sTfR, TfR1, Trfr, T9, p90 |
| Accession | A0A2K5X958 |
| Amino Acid Sequence | Cys89-Phe760, with N-terminal 10*His HHHHHHHHHHGGGSGGGSCKGVEPKTECERLAGTESPAREEPEEDFPAAPRLYWDDLKRKLSEKLDTTDFTSTIKLLNENLYVPREAGSQKDENLALYIENQFREFKLSKVWRDQHFVKIQVKDSAQNSVIIVDKNGGLVYLVENPGGYVAYSKAATVTGKLVHANFGTKKDFEDLDSPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVKADLSFFGHAHLGTGDPYTPGFPSFNHTQFPPSQSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTDSTCKMVTSENKSVKLTVSNVLKETKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSSVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQDVKHPVTGRSLYQDSNWASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELVERIPELNKVARAAAEVAGQFVIKLTHDTELNLDYERYNSQLLLFLRDLNQYRADVKEMGLSLQWLYSARGDFFRATSRLTTDFRNAEKRDKFVMKKLNDRVMRVEYYFLSPYVSPKESPFRHVFWGSGSHTLSALLESLKLRRQNNSAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF |
| Expression System | HEK293 |
| Molecular Weight | 83-90kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Kawabata H. (2019) Transferrin and transferrin receptors update. Free Radic Biol Med. 133:46-54. 2、Daniels T R. et al. (2006) The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer. Clin Immunol. 121: 144-158. |
Background
The major protein essential for the uptake of iron is transferrin receptor (TfR), encoded by TFRC, which is found primarily as a homodimer. TfR is a type II transmembrane glycoprotein that is endocytosed from the cell membrane after binding iron with transferrin (Tf), a serum iron carrier protein. TfR was found to affect many aspects of tumorigenesis, such as cancer cell proliferation, migration, invasion, metastasis and apoptosis. TfR expression was consistent with the asthma severity index, especially the proinflammatory M1 macrophage phenotype. TfR expression may be a good marker to indicate asthma severity. Increased TfR expression and decreased methylation levels of TfR were strongly correlated with multiple clinicopathological parameters. Elevated TfR expression was associated with a poor survival rate in BC patients. TfR is a new independent prognostic biomarker and a potential target for immunotherapy in BC.
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4.3 ★★★★★
Based on 15 reviews
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Product Reviews
★★★★★ 5
It holds all my gear and looks fantastic!!
Color: Rustic Montana, Size: 11.5" x 8" x 2", Color: Rustic Montana, Size: 11.5" x 8" x 2"
I wanted something to hold EVERYTHING. In the pic - 2 wallets, tactical flashlight, 2 personal bluetooth speakers, 2 pairs of Beats, chap stick, pocketknife. Missing are my reading glasses but they typically will fit in there too even in their protective sleeve. This would make a great gift and the leather is excellent feel and look. This is the Extra Large size and i am happy i went with the bigger one as i almost didnt. Wife thought it was a great purchased but mad that she didnt get the chance to gift it to me for Father's Day or birthday!! LOL
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 9, 2024
★★★★★ 5
Unique Jewelry Holder
Color: A White, Color: A White
Beautiful jewelry holder. Great for a gift but I brought this for myself. It arrives in 2 pieces that are easy to put together. It looks great on my dresser and helps to organize my jewelry.
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Reviewed in the United States on December 22, 2025
★★★★★ 5
Nice gift
Color: A White
It was a gift . She was pleased . Decorative.
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Reviewed in the United States on April 2, 2026
★★★★★ 4
Cute
Color: A White, Color: A White
It's super cute and goes well with the decor in my room. Comes with a leather bottom and easy to put together. Only problem is that's is a easy to fall apart as well. If one side is heavier then the other it will be lopsided. Holds necklaces okay... if you have heavy charms on them they will fall off.
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Reviewed in the United States on March 19, 2025
★★★★★ 3
Disappointing
Color: A White
The plastic was a little cheaper than I thought it would be, and the whole thing was a little smaller than I was picturing, you aren't able to rest necklaces on it because it's too short. Unfortunately I got it as a gift for someone else so I can't speak to its longevity but it was a bit disappointing.
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Reviewed in the United States on April 24, 2025