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Description
Frizzled-4/FZD4 His Tag Protein, HumanProduct Specification Species Human Synonyms hFz4, FzE4, CD344, Frizzled 4, Fz 4, EVR1, CD344, FZD4S, FEVR, GPCR Accession Q9ULV1 Amino Acid Sequence Phe37 Glu180, with C terminal 8*His FGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEEGGGSHHHHHHHH Expression System HEK293 Molecular Weight 20 28kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation
Product Specification
| Species | Human |
| Synonyms | hFz4, FzE4, CD344, Frizzled 4, Fz-4, EVR1, CD344, FZD4S, FEVR, GPCR |
| Accession | Q9ULV1 |
| Amino Acid Sequence | Phe37-Glu180, with C-terminal 8*His FGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEEGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 20-28kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Nallathambi J. et al. (2006) Identification of novel FZD4 mutations in Indian patients with familial exudative vitreoretinopathy. Mol Vis. 12: 1086-1092. 2、Sjöblom T. et al. (2006) The consensus coding sequences of human breast and colorectal cancers. Science. 314(5797): 268-274. |
Background
Frizzled-4, designated CD344, is a 7-transmembrane glycoprotein of the Frizzled family within the G-protein coupled receptor superfamily. Frizzled proteins function as receptors for Wnt proteins and can activate canonical Wnt/beta-catenin signaling as well as planar cell polarity and calcium flux pathways. Frizzled-4 is particularly important in angiogenic Wnt pathway signaling. Frizzled4 plays a crucial role in maintaining the integrity of the blood-brain barrier/blood-eye barrier, and regulating the expression of related proteins in the Frizzled4/Norrin pathway can regulate the switching of the blood-brain/blood-eye barrier. Frizzled-4 plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP).
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4.5 ★★★★★
Based on 11 reviews
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Product Reviews
★★★★★ 5
Didn’t know what to expect and was pleasantly surprised
Purchased to go along with the staedtler color markers. Mostly writing on laminate and loksaks. Works well and allows you to easily wipe off any permanent marker. Curious as to how long it’ll last. Keep a small cloth to wipe nib clean after use.
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Reviewed in the United States on February 21, 2025
★★★★★ 1
Waste of money
What a waste of money this was. After receiving this I was excited to try it out, my excitement soon turned to disappointment. No matter what I did, the only thing that I could get to come out was clear liquid. It immediately went into the trash.
Save your money and just go buy the BIC correction pen.
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Reviewed in the United States on March 29, 2026
★★★★★ 4
Works well
It works well to erase Staedtler permanent marker from an acetate map covering.
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Reviewed in the United States on November 4, 2025
★★★★★ 5
Nice
Took longer than expected. But durable
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Reviewed in the United States on September 27, 2025
★★★★★ 5
Exactly as described.
Exactly as described. And quick shipping by Amazon.
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Reviewed in the United States on September 17, 2025
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