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Description
Biotinylated LAIR2/CD306 His&Avi Tag Protein, HumanProduct Specification Species Human Synonyms LAIR2, CD306 Accession Q6ISS4 Amino Acid Sequence Gln22 Pro152, with C terminal 8*His&Avi tag QEGALPRPSISAEPGTVISPGSHVTFMCRGPVGVQTFRLEREDRAKYKDSYNVFRLGPSESEARFHIDSVSEGNAGLYRCLYYKPPGWSEHSDFLELLVKESSGGPDSPDTEPGSSAGTVPGTEASGFDAPIEGRMDHHHHHHHHGLNDIFEAQKIEWHE Expression System HEK293 Molecular Weight 20 25kDa Purity >95% by SDS PAGE Endotoxin <1EU g Conjugation Biotin Tag Avi Tag, His Tag Physical Appearance
Product Specification
| Species | Human |
| Synonyms | LAIR2, CD306 |
| Accession | Q6ISS4 |
| Amino Acid Sequence | Gln22-Pro152, with C-terminal 8*His&Avi tag QEGALPRPSISAEPGTVISPGSHVTFMCRGPVGVQTFRLEREDRAKYKDSYNVFRLGPSESEARFHIDSVSEGNAGLYRCLYYKPPGWSEHSDFLELLVKESSGGPDSPDTEPGSSAGTVPGTEASGFDAPIEGRMDHHHHHHHHGLNDIFEAQKIEWHE |
| Expression System | HEK293 |
| Molecular Weight | 20-25kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Biotin |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Lebbink R J. et al. (2008) The Soluble Leukocyte-Associated Ig-Like Receptor (LAIR)-2 Antagonizes the Collagen/LAIR-1 Inhibitory Immune Interaction. J Immunol. 180(3): 1662-1669. |
Background
The leukocyte-associated Ig-like receptor-2 (CD306) is an ITIM-containing inhibitory immune receptor, belonging to the Ig superfamily. LAIR-2 is encoded by a gene located in the vicinity of the LAIR-1 gene in the leukocyte receptor complex on human chromosome 19q13.4. The predicted LAIR-2 protein has a single Ig-like domain sharing 84% sequence homology with hLAIR-1, and the molecule lacks a transmembrane and cytoplasmic region suggesting it is a secreted protein. In contrast to hLAIR-1, LAIR-2 has no orthologs in mice or rats. The membrane ligand for LAIR-1 and LAIR-2 was expressed extensively and ligand recognition was of cross-species. LAIR-2 blocked the interaction of LAIR-1 with its ligand but LAIR-1 didn't block the interaction of LAIR-2 with its ligand. LAIR-2 had a higher affinity for collagen than did LAIR-1. LAIR-2 is a more potent antagonist of LAIR-1 function in vivo, while both sLAIR-1 and LAIR-2 are potential biomarkers. Recently shown that recombinant LAIR-2–His is able to interfere with collagen-induced platelet aggregation and that it efficiently inhibits the binding of collagen to glycoprotein VI and von Willebrand factor.
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4.6 ★★★★★
Based on 15 reviews
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Product Reviews
★★★★★ 4
Cute but small
Size: Large, Color: Skinny Green
Cute stuffy and has not yet ripped. While my dogs plays with it, the toy is a bit small for him. For reference he is 120lbs.
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Reviewed in the United States on May 27, 2026
★★★★★ 5
My Puppy Loves this Indestructible Dragon
Size: Large, Color: Pink, Size: Large, Color: Pink
My puppy (8 month old black lab mix) loves, loves, loves her dragon. She has had it for 2 months now. It is one of her favorites and gets daily rough play time. It's her go-to toy for fetch and tug games, as well as just general mouthy play. The squeaker gave out after about 4 weeks, but she would binge squeak for prolonged periods (kind of like chomping on gum) so it was almost a blessing when it went silent. She still chomps on it, but at least now I don't have to hear it. Other than the fact that it's a little grungy and bedraggled from so much loving, it is still in amazing shape. The seams and fur are all still intact. There are no visible holes, rips, or weak spots. I love Chew Guard Technology.
This dragon replaced her goDog Iguana (from PetSmart) that developed a tear in the fur after about 4 months of heavy use. (It was superficial, just the outer fur layer and not the innards, but we disposed of it before she could eat more fur.) She can be pretty rough on her toys and I can never predict if any given toy will last minutes or months. The goDog stuffies definitely fall into the "months" category, even with rough daily use.
Edit: The dragon lasted about 6 months of intensive, hard play before it developed a small tear in the fur. I patched it a couple times, but once my pup discovers a weak spot, it's the kiss of death for any stuffed item. We had to dispose of the dragon (so sad) to keep her from eating any more of the fur. We replaced the dragon with the goDog Chameleon, which is still going strong. I think we will go back to the dragon for our next toy because it's just so darned cute. We gave the dragon to my niece for her golden retriever puppy who is very chew-happy. That dragon is also doing well. You've just gotta love that chew-guard technology. This is one tough toy.
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Reviewed in the United States on September 26, 2015
★★★★★ 5
Precious toy for big dogs too
Size: Large, Color: Skinny Green
Not only is this toy cute and fun, but material is thick and durable even for my crazy GSP who is a destruction artist. This is, the favorite toy his go to in the toy box.
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Reviewed in the United States on May 15, 2026
★★★★★ 5
Indestructible Toys My Dobermans ❤️
Size: Large, Color: Mesh Green
Actually Respect! goDog Is a Lifesaver
The variety of size and colors are phenomenal 😇
I have two Dobermans — serious, determined power chewers — and I’ve spent years trying to find toys that survive even a few days.
I’ve tried the big brands (Kong, Goughnuts, Jolly Ball, you name it) — and while some toys last a little while, almost everything eventually ends up shredded, de-squeaked, or in pieces.
goDog toys are the ONLY plush toys my Dobermans won’t destroy.
We own multiple goDog toys now — dragons, dinosaurs, lizards — mostly in the large size (perfect for Dobermans), but even a few medium-sized ones hold up surprisingly well.
Here’s what’s amazing:
• They love them — actually carry them around, toss them, chew them gently, and squeak them happily.
• They do not rip them apart — no matter how much tugging, chewing, or wrestling happens.
• Large sizes are best for Dobermans (and other big breeds) — but even mediums survive for calmer play sessions.
• No ripped seams, no stuffing everywhere, and no destroyed squeakers after months of use.
What makes goDog toys different?
The secret is their Chew Guard Technology —
• A reinforced, high-strength inner mesh layer under the soft plush
• Double-stitched seams
• Durable yet flexible material that somehow resists punctures, tears, and brutal shaking
The outside stays soft and fun, but the inside is built like armor.
It’s NOT a super hard rubber or rough canvas — it still feels like a cuddle toy, but it’s engineered to survive serious chewing.
Materials include:
• Durable polyester plush
• Chew Guard inner lining (high-tensile mesh fabric)
• Reinforced stitching
• Non-toxic squeakers
• Safe for dogs to play with long-term
Real Owner Advice:
• Always size up if you have a heavy chewer — large sizes are a must for Dobermans or similarly strong breeds.
• Medium sizes are fine if you supervise or your dog is more moderate with toys, but the large toys are built tougher overall.
Final Thoughts:
If you have big dogs, strong jaws, or just tired of wasting money on destroyed toys — goDog toys are a must.
No other plush-style toy even comes close.
My Dobermans will destroy almost anything… but they treat their goDog toys like treasured companions. No holes, no rips, just happy dogs.
Follow me here on Amazon for more honest, dog-tested reviews! Like this review if it helped — I’ll be uploading even more proven tough toys and pet essentials soon!
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Reviewed in the United States on April 29, 2025
★★★★★ 4
Surface Fabric is very durable
Size: Small, Color: Hot Pink
Surface Fabric is very durable, but the squeaker didn't last two months. I have urged the manufacturer to find a strong more durable squeaker for their product. My dogs really enoys it when the speaker works. One of his 3 work. I have just bought two more he likes them so much. He takes it to bed every night to catch it once or twice before sleeping. Also loves to catch it a few times during the day.
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Reviewed in the United States on April 11, 2026