SKU: 6367119225

FGL1 Fc Chimera Protein, Human

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Description

FGL1 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms FGL1, Hepassocin, HP 041, HFREP 1, LFIRE 1 Accession Q08830 Amino Acid Sequence Leu23 Ile312, with N terminal Human IgG1 Fc Expression System HEK293 Molecular Weight 60 66kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure

Product Specification


Species Human
Synonyms FGL1, Hepassocin, HP-041, HFREP-1, LFIRE-1
Accession Q08830
Amino Acid Sequence Leu23-Ile312, with N-terminal Human IgG1 Fc
Expression System HEK293
Molecular Weight 60-66kDa
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag Human Fc Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.

Reference

1、Wang J. et al. (2019) Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3. Cell. 176: 334–347.

2、Wu H T. et al. (2016) A novel hepatokine, HFREP1, plays a crucial role in the development of insulin resistance and type 2 diabetes. Diabetologia. 59: 1732–1742.

3、Demchev V. et al. (2013) Targeted deletion of fibrinogen like protein 1 reveals a novel role in energy substrate utilization. PLoS ONE. 8: e58084.

Background

Hepassocin, also known as Hepatocyte-derived fibrinogen-related protein 1 (HFREP-1) and Fibrinogen-Like Protein 1 (FGL1), is a liver-specific secreted protein belonging to the fibrinogen superfamily whose members share a fibrinogen domain at their C-termini. FGL1 is a 68-KD protein comprised of a disulfide bond-linked homodimer. Its carboxyl terminus contains the β and γ subunits, which are highly homologous to fibrinogen but irrelevant to coagulation-related binding sites. Under normal physiological conditions, FGL1 is secreted mainly by hepatocytes in the liver (some of which may also exist in the pancreas). It is now clear that FGL1 is the product of hepatocyte regeneration and participates in hepatocyte mitosis and liver energy utilization (including lipid metabolism and blood glucose regulation). Apart from the above functions, FGL1 can also be detected in the plasma as an acute reactant, implying that FGL1 secreted by the liver acts not only on hepatocytes (autocrine) but also on other tissues, such as muscle and brown adipose tissues (telecrine). Under stimulation by metabolic factors (hyperglycemia, hyperlipidemia, hormones, etc.), the liver secretes FGL1 and participates in the blood circulation. This function of FGL1 acts on brown adipose tissue, regulates body productivity and maintains body temperature. Moreover, FGL1 also acts on muscle tissue and affects the sensitivity of myoblasts to insulin.

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SKU: 6367119225

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Amazon Customer
Port Orchard, US
★★★★★ 5
Durable, high-bounce dog balls that hold up well to energetic play
Color: D) 4-Pack 3" Balls (Yellow)
The Chew King 3-inch rubber balls have been great for active play sessions. The rubber feels thick and durable, and the bounce is surprisingly lively compared to many standard dog balls. They’re the perfect size for medium to large dogs and are easy for dogs to carry, chase, and retrieve. After repeated games of fetch, the surface has held up well without cracking or losing its shape. One thing that stands out is how easy they are to clean. Dirt and slobber rinse off quickly, so they’re ready for the next round of play. The bright color also makes them easier to find in grass or bushes compared to darker toys. For longer life, it helps to supervise play if your dog is a very aggressive chewer, since these are designed more for fetch than constant chewing. Also, rotating toys every few days can keep dogs more engaged and extend the lifespan of each ball. Overall, this is a solid set of durable fetch balls that provide great bounce and reliable outdoor playtime fun.
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Reviewed in the United States on March 5, 2026
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WilliamR
Belleville, US
★★★★★ 5
toughest dog balls in the world
Color: E) 8-Pack 2.5" Balls (Yellow), Color: E) 8-Pack 2.5" Balls (Yellow)
best balls in the universe. I have a 70# pit bull and a 120# presa canaria. All the other balls I bought lasted maybe 3 weeks, I have had these for over a year and play with them and the dogs 5-6 days a week. They still look brand new, They seem like they will last a year or so and they are both serious chewers. A presa has a bite force od about 525psi, twice a pitty
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Reviewed in the United States on April 24, 2026
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ZZmum
Cuba, US
★★★★★ 5
They worked out great!!!
Color: D) 4-Pack 3" Balls (Yellow), Color: D) 4-Pack 3" Balls (Yellow)
So far have been the solution we were looking for! I was extremely tired of the non stop destruction and order of large Chuckit balls for our high energy/high drive dog. For about the same price I bought four 3 inch balls to test out their durability and fit for the thrower. THEY WORK! Perfection! They even make a fun whistling sound as they sail through the air. They do require a tad more muscle in the thrower but that is not a problem. They have already shown to be WAY more durable. The 3 inch balls work in the large chunkit thrower. Super find.
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Reviewed in the United States on April 9, 2026
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HEATHER
Grantham, US
★★★★★ 4
Durable
Color: E) 8-Pack 2.5" Balls (Yellow)
My dogs love them. They are very bouncy, and ideal size, and durable. Great alternative to a tennis ball which in my house only last 30 minutes.
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Reviewed in the United States on March 23, 2026
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Kindle Customer
Battle Creek, US
★★★★★ 5
Toughest dang balls I ever played with
Color: D) 4-Pack 3" Balls (Yellow), Color: D) 4-Pack 3" Balls (Yellow)
These things are amazing. We have a ball obsessed Husky mix and he has destroyed Kongs, Chuck Its, and a whole lot of other ball shaped objects. These things? We bought the 4 pack because we bought 4 Chuck Its and they lasted a year, all 4 of them only a year, before they were destroyed. A year after buying these? We only bought more because he lost 3 of them. I think we did find one under the dresser after buying this pack... But the others? They either ended up thrown over the fence into the woods or lost in the holes in the yard the monster digs up. Other than a few pockmarks from his teeth and maybe some mud, they may as well be brand new even after a year or two. Probably the most chew resistant thing we've ever bought him. They're really solid rubber and since he hasn't managed to bite into them to take out a chunk, they're safe as hell. Being as big as they are, I don't worry he's gonna choke unattended on them like the usual size of ball. About the only concern is forcing breaks so he can have breathing moments when he manages to talk us into fetch outside. It fits in the larger Chuck It thrower too, so we haven't lost any value from having those torn up.
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Reviewed in the United States on April 26, 2026

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