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Description
Invivo anti-Mouse CD122 (IL-2Rβ) Recombinant mAbProduct Specification Host Rat Antigen CD122 (IL 2R) Synonyms Interleukin 2 receptor subunit beta; IL 2 receptor subunit beta; IL 2R subunit beta; IL 2RB; High affinity IL 2 receptor subunit beta; p70 75; Il2rb Location Cell membrane Accession P16297 Clone Number S 4060 Antibody Type Rat mAb Isotype Rat IgG2b,k Application FCM, Functional Assay, In vivo CD122 blockade Reactivity Ms Purification Protein G Concentration 5 mg ml Purity >95%(Determined by
Product Specification
| Host | Rat |
| Antigen | CD122 (IL-2Rβ) |
| Synonyms | Interleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; High affinity IL-2 receptor subunit beta; p70-75; Il2rb |
| Location | Cell membrane |
| Accession | P16297 |
| Clone Number | S-4060 |
| Antibody Type | Rat mAb |
| Isotype | Rat IgG2b,k |
| Application | FCM, Functional Assay, In vivo CD122 blockade |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95%(Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Background
CD122, also known as the Interleukin-2 Receptor Beta subunit (IL-2Rβ), is a crucial cell surface receptor protein. It is primarily expressed on immune cells such as activated T cells, Natural Killer (NK) cells, and some memory T cells. While CD122 itself cannot bind to its ligands (e.g., IL-2, IL-15) with high affinity, it is an indispensable component of the functional high-affinity receptor complex. It assembles together with the ligand-specific alpha subunit (CD25) and the common gamma chain subunit (CD132), which is responsible for signal transduction. The intracellular domain of CD122 is directly linked to several key signaling pathways, most notably the JAK-STAT pathway. Upon binding with IL-2 or IL-15, it transduces essential signals that promote immune cell proliferation, survival, and functional activation. Consequently, CD122 plays a central role in the initiation, maintenance, and regulation of both adaptive and innate immune responses. Dysfunction of CD122 is closely associated with various pathological processes, including autoimmune diseases, transplant rejection, and tumor immune evasion. This also makes it an important potential therapeutic target for immunotherapies, such as agonist antibodies.
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