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Description
TfR/CD71 His Tag Protein, HumanProduct Specification Species Human Synonyms TfR, CD71, TFRC, TFR, sTfR, TfR1, Trfr, T9, p90,transferrin receptor Accession P02786 Amino Acid Sequence Cys89 Phe760, with N terminal 10* His
Product Specification
| Species | Human |
| Synonyms | TfR, CD71, TFRC, TFR, sTfR, TfR1, Trfr, T9, p90,transferrin receptor |
| Accession | P02786 |
| Amino Acid Sequence | Cys89-Phe760, with N-terminal 10* His HHHHHHHHHHGGGSGGGSCKGVEPKTECERLAGTESPVREEPGEDFPAARRLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSKVWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTKKDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFGHAHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQFLYQDSNWASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFVIKLTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDFGNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRKQNNGAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF |
| Expression System | HEK293 |
| Molecular Weight | 80-87kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Kawabata H. (2019) Transferrin and transferrin receptors update. Free Radic Biol Med. 133:46-54. 2、Daniels T R. et al. (2006) The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer. Clin Immunol. 121: 144-158. 3、Gatter K C. et al. (1983) Transferrin receptors in human tissues: their distribution and possible clinical relevance. J Clin Pathol. 36: 539-545. |
Background
The major protein essential for the uptake of iron is transferrin receptor (TfR), encoded by TFRC, which is found primarily as a homodimer. TfR is a type II transmembrane glycoprotein that is endocytosed from the cell membrane after binding iron with transferrin (Tf), a serum iron carrier protein. TfR was found to affect many aspects of tumorigenesis, such as cancer cell proliferation, migration, invasion, metastasis and apoptosis. TfR expression was consistent with the asthma severity index, especially the proinflammatory M1 macrophage phenotype. TfR expression may be a good marker to indicate asthma severity. Increased TfR expression and decreased methylation levels of TfR were strongly correlated with multiple clinicopathological parameters. Elevated TfR expression was associated with a poor survival rate in BC patients. TfR is a new independent prognostic biomarker and a potential target for immunotherapy in BC.
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