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Description
Mouse IFN-γ Recombinant Rabbit mAb (SDT-1562-34)Product Specification Host Rabbit Antigen IFN Immunogen Recombinant Protein Accession P01580 Clone Number SDT 1562 34 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Cross Reactivity No cross reactivity against rat IFN , mouse TNF Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt, 2 to 8 C
Product Specification
| Host | Rabbit |
| Antigen | IFN-γ |
| Immunogen | Recombinant Protein |
| Accession | P01580 |
| Clone Number | SDT-1562-34 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Cross Reactivity | No cross-reactivity against rat IFN-γ, mouse TNF-α |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
Interferon gamma (IFN-γ) is a cytokine critical to both innate and adaptive immunity, and functions as the primary activator of macrophages, in addition to stimulating natural killer cells and neutrophils. A non-IgE-mediated anaphylactic reaction and severe bronchospasm have been reported once after the first injection of interferon gamma. IFN-γ activates cells via a different receptor than IFN-α and IFN-β, which accounts for the different physiological properties of the proteins. Production of IFN-γ is largely restricted to activated CD4+ TH1 T cells, CD8+ T cells, and natural killer cells. One of the most important consequences of IFN-γ secretion is the activation of macrophages. In addition, IFN-γ plays a central role in inflammatory responses by activating endothelial cells, promoting TH1 cell development and cellular immune responses, and up-regulation of major histocompatability complex protein expression on antigen-presenting cells.
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