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Description
M-CSFR His Tag Protein, HumanProduct Specification Species Human Synonyms M CSFR, CD115, FIM2, FMS, CSF1R Accession P07333 Amino Acid Sequence Ile20 Glu512, with C 8*His Expression System HEK293 Molecular Weight 75 90kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation.
Product Specification
| Species | Human |
| Synonyms | M-CSFR, CD115, FIM2, FMS, CSF1R |
| Accession | P07333 |
| Amino Acid Sequence | Ile20-Glu512, with C-8*His |
| Expression System | HEK293 |
| Molecular Weight | 75-90kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Sapi E. et al. (1999) The role of CSF-1 in normal and neoplastic breast physiology. Proc Soc Exp Biol Med. 220(1): 1-8. 2、Sapi E. (2004) The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update. Exp Biol Med (Maywood). 229(1): 1-11. 3、Bonifer C. et al. (2008) The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis. Front Biosci. 13: 549-560. |
Background
Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the type Ⅲ subfamily of receptor tyrosine kinases. M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region. M-CSF receptor is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta. M-CSF R engagement is continuously required for macrophage survival and regulates lineage decisions and maturation of monocytes, macrophages, osteoclasts and DC. M-CSF R and integrin alpha v beta 3 share signaling pathways during osteoclastogenesis and deletion of either causes osteopetrosis. In the brain, microglia expressing increased M-CSF R are concentrated with Alzheimers a beta peptide, but their role in pathogenesis is unclear.
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4.6 ★★★★★
Based on 22 reviews
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Product Reviews
★★★★★ 5
DERM APPROVED!
I am obsessed with this product!! This feels very luxurious on my skin and does not pill like other products I have had in the past. I have noticed a significant improvement in the background redness in my skin. As someone who works in derm and values good ingredients and products that actually work... I can confidently say that this is the best OTC azelaic acid product I have tried out. It sits very nicely under my moisturizer and does not dehydrate my skin like other azelaic acid products have done in the past. HIGHLY RECOMMEND
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Reviewed in the United States on May 10, 2026
★★★★★ 5
A Game Changer for Sensitive Skin
I use this serum every single day, and it has become one of the most important products in my skincare routine. I have very sensitive skin and cannot tolerate stronger active ingredients such as retinol or high-strength acids, so finding something effective but gentle has been incredibly important.
This serum has helped calm redness, reduce inflammation, and noticeably improve my skin’s overall appearance and comfort. After dealing with a prolonged inflammatory skin condition, this product made a significant difference and helped restore my skin barrier.
The formula feels soothing, hydrating, and non-irritating. If you have sensitive or reactive skin and are looking for a gentle product to help with redness and uneven texture, I highly recommend giving this serum a try.
Photos attached: The green bottle is the product and the second photo includes my favorite additions.
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Reviewed in the United States on May 13, 2026
★★★★★ 5
Perfect for Acne-Prone Skin!
This serum has honestly been a great addition to my routine for redness and post-acne marks. The texture is lightweight, hydrating, and doesn’t feel sticky or heavy on my oily/acne-prone skin.
I have sensitive skin with a focus on barrier protection, and this didn’t irritate my skin at all. It layers beautifully with the rest of my skincare and leaves my skin looking calmer and smoother over time. AND, it doesn’t have a smell!!
Definitely one of my favorite azelaic acid serums I’ve tried.
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Reviewed in the United States on May 18, 2026
★★★★★ 5
6-Month Update: Still a staple for sensitive, acne-prone skin
Size: 3.38 Fl Oz (Pack of 1), Size: 3.38 Fl Oz (Pack of 1)
I originally reviewed this ampoule when I first started using it, and now after about six months of consistent use (morning and night), I feel confident giving a more long-term update.
I have sensitive, acne-prone, combination skin, and this has remained one of the most reliable products in my routine. The texture is still one of my favorite things about it — very lightweight, absorbs quickly, and layers well under moisturizer and sunscreen without pilling.
Over time, I’ve noticed:
Less visible redness
More balanced oil production in my T-zone
Fewer irritation flare-ups when introducing new products
No clogged pores or breakouts from this formula
It doesn’t feel heavy or sticky, even in humid weather. I’ve continued repurchasing and even keep it on subscription because it consistently performs without causing sensitivity.
If you’re looking for a gentle, soothing centella product that works well for long-term barrier support, this has proven to be a dependable option in my experience.
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Reviewed in the United States on December 9, 2025
★★★★★ 5
Healed my barrier so fast
Size: 3.38 Fl Oz (Pack of 1)
I received this ampoule yesterday and I'm already leaving a 5 star review after 2 uses because it just worked so well. I bought it because I've recently incorporated the Timeless 20% Vitamin C into my routine and that + my tretinoin made my skin drier than I've ever felt it before, even gently swiping a cotton pad with micellar would sting on some parts of my face. As soon as this ampoule arrived I applied it to clean skin and layered squalane on top (my moisturizer was burning as well.) This product did not sting my face AT ALL. It instead felt immediately soothing and hydrating. When I woke up this morning almost all of my redness was gone, my skin didn't feel tight or irritated, and my skin tone looked so even and glowy. I never thought a product, especially such a simply formulated one, could heal my barrier so quickly but that's exactly what it did and I can already tell it's a repeat buy. If you have redness prone sensitive skin and/or you use several high strength actives, this ampoule is a must have and it might be the key for anyone struggling to tolerate high strength retinoids. I got the largest size bottle for $15 on sale and it's seriously one of the most affordable and effective skincare products I've ever had in my routine.
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Reviewed in the United States on May 30, 2026
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